2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-124320
    Desmethylene paroxetine hydrochloride
    Desmethylene paroxetine hydrochloride is a major urinary metabolite of Paroxetine. Paroxetine is a potent serotonin reuptake inhibitor.
    Desmethylene paroxetine hydrochloride
  • HY-W016388R
    9-Fluorenol (Standard)
    9-Fluorenol (Standard) is the analytical standard of 9-Fluorenol. This product is intended for research and analytical applications. 9-Fluorenol (9-Hydroxyfluorene; compound 3) is a dopamine (DAT) inhibitor with IC50 value of 9 μM. 9-Fluorenol is a major metabolite of compound developed as a wake promoting agent. 9-Fluorenol shows wake promotion activity in vivo.
    9-Fluorenol (Standard)
  • HY-118100
    Cyclo(Tyr-Val)
    Cyclo(Tyr-Val) (Cyclo(L-Tyr-L-Val)) is a diketopiperazine secondary fungal metabolite originally isolated from N. gilva.
    Cyclo(Tyr-Val)
  • HY-W424792A
    O-Desmethyl Brinzolamide hydrochloride
    O-Desmethyl Brinzolamide hydrochloride (compound 6a), an active metabolite of Brinzolamide, is a carbonic anhydrase (CA) inhibitor with a Kd of 0.136 nM for CA II and an IC50 of 165 nM for CA IV.
    O-Desmethyl Brinzolamide hydrochloride
  • HY-12769S1
    Mebeverine acid-d5 hydrochloride
    		≥99.0%
    Mebeverine acid-d5 (hydrochloride) is deuterium labeled Mebeverine acid.
    Mebeverine acid-d<sub>5</sub> hydrochloride
  • HY-B1984R
    p,p'-DDD (Standard)
    p,p'-DDD (Standard) is the analytical standard of p,p'-DDD. This product is intended for research and analytical applications. p,p'-DDD is a major metabolite of p,p'-DDT. p,p'-DDD occurs in the feces and livers of rats, that are given p,p'-DDT by stomach tube, but not of rats injected intraperitoneally with p,p'-DDT.
    p,p'-DDD (Standard)
  • HY-100657
    meta-Fexofenadine
    meta-Fexofenadine (meta-MDL-16455) is an impurity of Fexofenadine. Fexofenadine, a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial.
    meta-Fexofenadine
  • HY-135731AS
    4-Methylamino antipyrine-d3 hydrochloride
    4-Methylamino antipyrine-d3 (hydrochloride) is deuterium labeled 4-Methylamino antipyrine (hydrochloride). 4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever[1][2][3]. 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties[2].
    4-Methylamino antipyrine-d<sub>3</sub> hydrochloride
  • HY-133247
    Daclatasvir Impurity B
    Daclatasvir Impurity B is the impurity of Daclatasvir. Daclatasvir is a potent HCV NS5A protein inhibitor.
    Daclatasvir Impurity B
  • HY-N9484
    Menthofuran
    Menthofuran is a proximate toxic metabolite of (R)-(+)-Pulegone. Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase.
    Menthofuran
  • HY-150092S
    (2S,3R)-8(9)-EET-d11
    (2S,3R)-8(9)-EET-d11 is deuterium-labeled (2S,3R)-8(9)-EET (HY-150092).
    (2S,3R)-8(9)-EET-d<sub>11</sub>
  • HY-136445
    Terbuthylazine-desethyl
    Terbuthylazine-desethyl (Desethylterbuthylazine) is a chloro dealkylated metabolite of Terbuthylazine (a triazine herbicide).
    Terbuthylazine-desethyl
  • HY-N10594
    Cirsiliol 4′-glucoside
    Cirsiliol 4′-glucoside is a free radical scavenger, found from Ruellia tuberosa L. Cirsiliol 4′-glucoside shows potential anti-diabetic activity.
    Cirsiliol 4′-glucoside
  • HY-143997S
    (Rac)-Nicotine EP impurity A-d4 hydrochloride
    (Rac)-Nicotine EP impurity A-d4 (hydrochloride) is the deuterium labeled (Rac)-Nicotine EP impurity A hydrochloride[1].
    (Rac)-Nicotine EP impurity A-d<sub>4</sub> hydrochloride
  • HY-116026
    3-Hydroxycarbofuran
    3-Hydroxycarbofuran, a major metabolite of Carbofuran, is a reversible acetylcholinesterase (AChE) inhibitor.
    3-Hydroxycarbofuran
  • HY-W016099
    3-Methyl-2-quinoxalinecarboxylic acid
    3-Methyl-2-quinoxalinecarboxylic acid (MQCA), an important N-oxide reductive metabolite of Quinocetone or Olaquindox, potently inhibits the growth of Chang liver cells through S phase arrest of the cell cycle.
    3-Methyl-2-quinoxalinecarboxylic acid
  • HY-N7781R
    (-)-(E)-Guggulsterone (Standard)
    (-)-(E)-Guggulsterone (Standard) is the analytical standard of (-)-(E)-Guggulsterone. This product is intended for research and analytical applications. (-)-(E)-Guggulsterone is the metabolite of Z-guggulsterone. Guggulsterone is an active constituent of guggulipid, an ayurvedic agent derived from Commiphora mukul. Guggulsterone has hypolipidaemic activity.
    (-)-(E)-Guggulsterone (Standard)
  • HY-137188
    Perindopril acyl-β-D-glucuronide
    Perindopril acyl-β-D-glucuronide is a metabolite of Perindopril (HY-B0130). Perindopril is an ACE inhibitor.
    Perindopril acyl-β-D-glucuronide
  • HY-133794S
    Dasatinib N-oxide-d8
    Dasatinib N-oxide-d8 is the deuterium labeled Dasatinib N-oxide. Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor[1][2].
    Dasatinib N-oxide-d<sub>8</sub>
  • HY-B1398S
    Ampyrone-d3
    Ampyrone-d3 is the deuterium labeled Ampyrone. Ampyrone is a reagent for glucose determination in the presence of peroxidase and phenol.
    Ampyrone-d<sub>3</sub>
Cat. No. Product Name / Synonyms Application Reactivity